School Bus Monitors in Western New York

The New York State Department of Education defines a “bus monitor” (also commonly referred to as a “bus aide”) as any person employed for the purpose of assisting children to safely embark and disembark from a school bus which is owned, leased or contracted for by a public school district or board of cooperative educational services, and for the purpose of assisting the school bus driver with maintaining proper student behavior on such school bus

Community Change for Youth Development in Kansas City

Kansas City, Missouri, is one of six sites in Community Change for Youth Development (CCYD), a national demonstration project aiming to increase basic supports and opportunities available to youth aged 12-20. The lead agency is the YMCA of Greater Kansas City; because of its considerable organizational capacity and relationship with funders, the YMCA was successful in operating and expanding CCYD. This report focuses on the benefits of working with the YMCA of Greater Kansas City and the challenges faced by the organization in leading a community-based initiative in three urban neighborhoods

An MBA Capstone Consulting Experience in the Midst of COVID-19

In alignment with Molloy College’s commitment to civic engagement, the MBA program requires prospective graduates to complete its Capstone course, which entails providing consulting services to a not-for-profit organization. The course requires students to apply their cross-disciplinary knowledge and skills to solve real problems for their clients. In one short semester, students must form working relationships with fellow project members, develop an understanding of their client’s mission and objectives, and propose solutions that address their client’s challenging problems. The semester culminates with the delivery of a written proposal, a formal presentation to the client, and a final reflection. This paper describes the consulting problems faced by a class of Spring 2020 MBA students and the additional challenges they encountered due to the COVID-19 epidemic. It also describes the local organization the students worked with (the I’m Not Done Yet Foundation) and the solutions the students designed to increase awareness of the organization, improve its financial position, and streamline its internal operations

Could a Kilonova Kill: a Threat Assessment

Binary neutron star mergers (BNS) produce high-energy emissions from several physically different sources, including a gamma-ray burst (GRB) and its afterglow, a kilonova, and, at late times, a remnant many parsecs in size. Ionizing radiation from these sources can be dangerous for life on Earth-like planets when located too close. Work to date has explored the substantial danger posed by the GRB to on-axis observers: here we focus instead on the potential threats posed to nearby off-axis observers. Our analysis is based largely on observations of the GW 170817/GRB 170817A multi-messenger event, as well as theoretical predictions. For baseline kilonova parameters, we find that the X-ray emission from the afterglow may be lethal out to $\sim 5$ pc and the off-axis gamma-ray emission may threaten a range out to $\sim 4$ pc, whereas the greatest threat comes years after the explosion, from the cosmic rays accelerated by the kilonova blast, which can be lethal out to distances up to $\sim 11$ pc. The distances quoted here are typical, but the values have significant uncertainties and depend on the viewing angle, ejected mass, and explosion energy in ways we quantify. Assessing the overall threat to Earth-like planets, have a similar kill distance to supernovae, but are far less common. However, our results rely on the scant available kilonova data, and multi-messenger observations will clarify the danger posed by such events.Comment: 21 pages, 5 figures. Comments welcom

The structure of a resuscitation-promoting factor domain from Mycobacterium tuberculosis shows homology to lysozymes

Resuscitation-promoting factor (RPF) proteins reactivate stationary-phase cultures of (G+C)-rich Gram-positive bacteria including the causative agent of tuberculosis, Mycobacterium tuberculosis. We report the solution structure of the RPF domain from M. tuberculosis Rv1009 (RpfB) solved by heteronuclear multidimensional NMR. Structural homology with various glycoside hydrolases suggested that RpfB cleaved oligosaccharides. Biochemical studies indicate that a conserved active site glutamate is important for resuscitation activity. These data, as well as the presence of a clear binding pocket for a large molecule, indicate that oligosaccharide cleavage is probably the signal for revival from dormancy

A Global Vision and Strategy for Organic Farming Research. First Draft.

Organic agriculture world-wide offers the promise of a future to produce and distribute food and other farm products in a healthy, ecologically sound, truly sustainable and fair way. The full benefits of organic agriculture are just now being realized—from ecosystem services to the provision of healthier food - yet, to reach its full potential organic farming needs to address many challenges. While organic agriculture has grown in strength and is in the most favorable position it has ever been in with respect to market conditions, government policies and international institutional support, it still does not have adequate resources to continue its expansion. The Technology Innovation Platform of IFOAM (TIPI) has developed a vision and an agenda to advance organic agriculture through research, development, innovation and technology transfer. TIPI’s vision recognizes that current technologies based on heavy use of external inputs that are toxic and pollute the environment come with a price. Investments in ecosystem services and the development of technologies that are productive, stable, adaptable, resilient, and fairly shared are much more likely to sustain the world’s population in a rapidly changing environment. Sustainable pathways to innovation will require engagement of all stakeholders in a science driven multi-disciplinary approach. Such an approach seeks to (1) Empower rural areas, (2) Provide eco-functional intensification that produces food and ecosystem services, and (3) Provide food for the health and well-being available to all. Organic agriculture must build the capacity to fulfill the world’s food needs for the entire population if it is to fulfill its mission. The new paradigm proposed by TIPI is founded upon a whole systems approach, the engagement of farmers, researchers and other practitioners in a co-innovative approach; and open access technologies that are readily adapted to local conditions. While there are barriers and bottlenecks that will need to be overcome for this vision to be realized, TIPI calls upon the organic community to support its 14 point action plan to advance organic agriculture in a forward-thinking and innovative way

High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease

Individual reports suggest that the central nervous system (CNS) contains multiple immune cell types with diverse roles in tissue homeostasis, immune defense, and neurological diseases. It has been challenging to map leukocytes across the entire brain, and in particular in pathology, where phenotypic changes and influx of blood-derived cells prevent a clear distinction between reactive leukocyte populations. Here, we applied high-dimensional single-cell mass and fluorescence cytometry, in parallel with genetic fate mapping systems, to identify, locate, and characterize multiple distinct immune populations within the mammalian CNS. Using this approach, we revealed that microglia, several subsets of border-associated macrophages and dendritic cells coexist in the CNS at steady state and exhibit disease-specific transformations in the immune microenvironment during aging and in models of Alzheimer's disease and multiple sclerosis. Together, these data and the described framework provide a resource for the study of disease mechanisms, potential biomarkers, and therapeutic targets in CNS disease

A nipple shield delivery system for oral drug delivery to breastfeeding infants : Microbicide delivery to inactivate HIV

A new drug delivery method for infants is presented which incorporates an active pharmaceutical ingredient (API)-loaded insert into a nipple shield delivery system (NSDS). The API is released directly into milk during breastfeeding. This study investigates the feasibility of using the NSDS to deliver the microbicide sodium dodecyl sulfate (SDS), with the goal of preventing mother-to-child transmission (MTCT) of HIV during breastfeeding in low-resource settings, when there is no safer alternative for the infant but to breastfeed. SDS has been previously shown to effectively inactivate HIV in human milk. An apparatus was developed to simulate milk flow through and drug release from a NSDS. Using this apparatus milk was pulsed through a prototype device containing a non-woven fiber insert impregnated with SDS and the microbicide was rapidly released. The total SDS release from inserts ranged from 70 to 100% of the average 0.07 g load within 50 ml (the volume of a typical breastfeed). Human milk spiked with H9/HIVIIIB cells was also passed through the same set-up. Greater than 99% reduction of cell-associated HIV infectivity was achieved in the first 10 ml of milk. This proof of concept study demonstrates efficient drug delivery to breastfeeding infants is achievable using the NSDS